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一种高致命性和传染性的病毒在世界上蔓延开来。为了避难，四个好朋友打算以最快速度穿越美国西南部的沙漠地带。他们渴望寻找一个相对安全的庇护所，然而在耗费整整几天时间后，他们逐渐意识到，这个偌大的国度或许早已没有他们的容身之所。不仅肆虐的病毒压迫着每个人的神经，他们更被迫直面那些超乎想象的生存困境与人性考验。很快他们便发现，横亘在面前的最大威胁并非持续侵袭人类的致命病毒，而是深藏于每个人心底的黑暗与邪恶……。The best man at Scott (Long) and Kristin's (Weixler) Arizona destination wedding, Lumpy (Labine) is the life of the party, until a long, indulgent night leads to his untimely death. Forced to cancel their honeymoon and fly back to Minneapolis to arrange for his funeral, Scott and Kristin meet Ramsey (Timlin) and learn that Lumpy isn't quite who they thought he was.。